Well, I've only just started, but:
I had a character going pretty well, had all phoenix feather limbs, relatively decent armour etc. I'd just taken out the enner beast for the first time, and I thought I'd pop down to the next level to check it out. There was some invisible critter hitting me pretty hard, which I lured back up the stairs and control teleported around to heal up and then came back and hit it until it died. Turns out it was the spider silk golem (I checked out the wiki), which was nice, I picked up the armour and the scroll and wands(hint hint), and went back down the stairs.
I cleared most of the level out, and I had started to pick up some loot, when I ran into this squat, cranky looking creature. Too late, I realised that this was a kamikaze dwarf (veteran, judging by the size of the bang).
All my limbs were blown off, and I think I died to the blast, but luckily I was wearing an amulet of lifesaving, which did its job. Unluckily, I also had a bag full of wands that chain exploded, blowing all my limbs off again, and killing me again (?? - I think so anyway). HOWEVER, I wasn't done yet, as I must have had a wand of resurrection or something; whatever happened, when all was said and done there I was, a mistress torture chief, with a clone, and the message "something is calling you back from the afterlife" (I'm not sure if I got that exactly right or not). I got off the level quickly, and just as well, as when I reverted to human I was limbless and down to near dead in all my vital organs.
Loricatus was kind enough to donate a bronze leg which allowed me to hobble back to New Attnam (all the other gods were angry with me for some reason - I lost an arm to Sophos just after I'd grown it with my last full healing potion - Mellis wasn't giving me anything either) and get my limbs back, and I'd cloned enough scrolls of change material to convert them all into phoenix feather again.
So, back into the gloomy cave I went, careful of all things with beards, and got down to level 7. Here I found a giant dark frog, one of which I'd killed before, so without a thought I went up and hit it. It wasn't pleased, and bit my head so hard that I was knocked out, then proceeded to bash me to death. This was a bit surprising, as I was wearing a super snazzy helmet and all (enlightenment, I think it's called, 5 too).
I can only say, the game lived up to its name.