The first time I saw the mage room, in wizard mode, with great gear, they killed me before I could make a dent in them. Since then I've favoured the overkill approach:
Amulet of elemental protection, as many other sources of electricity and fire resistance as possible. permanent invisibility, haste, telecontrol, phoenix feather and gef limbs, resurrected Sherarax, high endurance, dead or resurrected Ischaldirh, octagonal key, Turox/thunder hammer, lyre of charm, dulcis, scrolls of taming, explosives. Some of these are optional.
SPOILER ALERT. Click here to see text.Primary targets are:
* Things that affect your equipment, because your equipment lets you kill things and not die
* Things that can summon skeletons/zombies/golems, because they prevent you from getting into melee range of your primary targets
None of the mage room inhabitants are resistant to fire or electricity, so explosions are helpful.
Things you tame will not only stop acting against you, but also waste enemies's time.
Turox and thunder hammer are not actually that helpful as sources of area damage here, since they don't activate often enough. If you clear the mage room, it will happen fast.
Some mages don't have ESP or infravision, and can't summon anything. They are the lowest priority to kill.
If you are surrounded by low-priority targets, don't bother fighting them. Make an explosion or teleport.
Sometimes the mages will teleport you. Since you have telecontrol, that helps you - choose a square next to a primary target.
Don't try to tunnel through the octiron wall - use a key or make an explosion.
Not all characters get enough wishes/cloning charges for that collection to be really feasible, and the mage room is dangerous enough that so far I haven't even gone to GC10 in a normal game without being confident that I can handle them.
With natural limbs I don't know what the agi/dex requirements would be to take them on effectively. You need to be able to kill a mage and step on its corpse before a zombie is summoned.
I've never actually bothered to clear out the mage room - they teleport all over the place. I just kill the most dangerous ones to make sure the threat is neutralised.