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At the end is an item that lets you see ghosts (perhaps just an amulet of ESP), or maybe a way to turn ghosts off for the rest of the game. Why? There's ghost versions of half the monsters in the game, gives other things a change to spawn.
Or perhaps a wand (or more) of "Etherealification", which would, when zapped, turn a creature into a ghost form of itself (most likely permanently, but this could be temporary), henceforth dropping all of its loot. This would, obviously, have no effect on boss monsters, and would perhaps have only 1 (maybe 2) uses per charge (depending on the amount given). The use would be twofold: You would be much more likely to kill a monster in its ghost form, and then its loot would simply be yours for the taking.