I could forsee getting perma-confused by (un)intentionally eating too many mushroom corpses.
I do however agree that the permanent status effects "bug" should be left in. However... perhaps a liquid type could be added which clears all innate status effects? A potion of cleansing, effectively? Obviously it shouldn't work on status effects from worn items.
I still love my winning strategy. Started with a Turok. Got a Neerc se'Ulb. Trained aSTR until I could wield both... then I got another Neerc. Proceeded to turn everyone in my path into mushy piles of life-drained goo. Also proceeded to starve to death three times between GC and Attnam while carrying Elpuri's head.