Just for the gallows humor value, you should be able to set off the nuke. Ending the game immediately with a 0x score multiplier and a short list of random snarky lines such as " (player) tore the continent a new one", "(player) was reduced to component atoms", etc.
Per the Ideas page on the wiki, red_kangaroo has generously offered to add this idea with an appropriately-sized and colored ending screen, which I've got here
. A nice drawn-out explosion sound would really add to the effect, which shouldn't be hard to come by either.