Since the game tracks stats for each limb, I believe the attacks would be based on the weapon arm.

I've had trouble even with a magical whistle.

I've always had trouble getting Vlad to follow me.

You talkin' 'bout this?

Doesn't the dark archmage spawn on day 40 or so even if you don't meet the power requirements?

I've blown up crystals with big mines and backpacks of gunpowder before.

You do know that has more to do with your stats than with a particular level.

Aw, come on. Not every game is blessed with a wizard mode that let's you do just about anything

Now that he knows, I'm certain he'll make good use of it. We'll miss the activity

JoKe: If you have heavy explosives, you can blow up the crystals

4zb4: What boss monster? It often has invisible stalkers but I've never seen a boss down there

Leprosy is not recommended. Not only is limb-loss completely random, it'll also hit your stats. Angering Sophos is an interesting approach, and very do-able, points to Zulox for originality. It's really hard to find spell-casters that'll target limbs, and letting them take your limbs is dangerous, they'll probably kill you.