Choose your gods wisely. The gods you pray to make a huge difference in your playing style and abilities. It is possible to pray to a range of gods two allignment levels around your central god. As you get more wisdom this can be increased. For example. I choose Silva (Neutral +) as a central god and then I can pray to Mellis (N-) Loricatus (N), Silva, Sophos (Lawful -), Dulcis (L) and Seges (L) this allows me to do the following:
Mellis: 1) fill 5 empty cans/bottles/broken bottles/banana peels with random contents (except peels which always fill with banana) this generates food, Ommel fluids, potions, acid, booze, school food (gives a good endurance boost eat cans the pray to Seges) 2) Get gifts of expensives stones, copies of Petrus' left nut 3) get limbs
Loricatus 1) harden iron series items (weapons, armour etc.) sometimes to adamantine - a meteoric steel pick axe lets you mine crystals in UT4, hardened bear traps destroy powerful enemies. 2) get metal limbs
Silva 1) generate wolf packs for food or pets 2) earthquakes to reveal gems in GC levels, spring traps, explode mines, kill enemies, find hidden rooms, move Genetrix
3) get limbs some are kick ass eg. phoenix feather, ommel hair is god early
Sophos 1) last ditch escape random teleport (most not be missing a limb), 2) Gift of vermis, wand teleport, 3) best limbs ever - ommel cerumen
Dulcis 1) tame monsters for fun and profit, useful for Science talking to raise intelligence, tame guards and sell their equipment and or use as pets, 2) angel hair limbs, 3) best gift is lyre of charm, awesome for scitalking, taming kamikaze dwarves, giant dark frogs, mages
Seges 1) human limbs, 2) get filled with food, 3) cure poison or leprosy 4) gift of armour of great health, stethoscope
if i find valpurus or atavus early game i will often pray to them, atavus give an awesome gift of arcanite platemail and valpurus give valpurium shield or sword (I prefer the shield because there are better weapons int he game than the sword). you can then carefully drop these gods and add more neutral ones.